Keywords
Comorbidity
Infant, Newborn, Diseases
How to Cite
Abstract
Backround: Neonatal sepsis is a serious infection that affects newborns and can have significant complications. The clinical presentation can be non-specific, which makes timely diagnosis and treatment difficult.
Objective: To describe the clinical and epidemiological characteristics of neonatal sepsis in a tertiary hospital through a retrospective observational study.
Materials and Methods: The study is observational, descriptive, and retrospective, and medical records of all newborns admitted to the Neonatal Intensive Care Unit of the Hospital de Clínicas del Paraguay during January 2021 to December 2022 were analyzed. A non-probabilistic convenience sampling of consecutive cases will be used, and privacy and confidentiality of obtained data will be ensured.
Results: The study registered 270 live births admitted to the Hospital de Clínicas del Paraguay, of which 38 (14.07%) presented neonatal sepsis. In 2021 and 2022, 22 (14.6%) and 16 (13.3%) cases of neonatal sepsis were recorded, respectively. Associated comorbidities included cardiac, respiratory, neurological, and metabolic diseases. The most common treatment was a combination of ampicillin and gentamicin.
Conclusion: The research found a moderate incidence of neonatal sepsis in the Hospital de Clínicas del Paraguay, with the majority of cases registered in male patients. The most common comorbidities were metabolic and respiratory diseases, and most cases were of early-onset neonatal sepsis. Implementation of preventive measures such as promotion of breastfeeding and aseptic practices is suggested.
References
Fleischmann C, Reichert F, Cassini A, Horner R, Harder T, Markwart R, et al. Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis. Archives of Disease in Childhood. 1 de agosto de 2021;106(8):745-52.
Camargo JF de, Caldas JP de S, Marba STM. Early neonatal sepsis: prevalence, complications and outcomes in newborns with 35 weeks of gestational age or more. Rev paul pediatr. 4 de octubre de 2021;40:e2020388.
Acheampong EN, Tsiase JA, Afriyie DK, Amponsah SK. Neonatal Sepsis in a Resource-Limited Setting: Causative Microorganisms and Antimicrobial Susceptibility Profile. Interdisciplinary Perspectives on Infectious Diseases. 27 de mayo de 2022;2022:e7905727.
Adatara P, Afaya A, Salia SM, Afaya RA, Konlan KD, Agyabeng-Fandoh E, et al. Risk Factors Associated with Neonatal Sepsis: A Case Study at a Specialist Hospital in Ghana. The Scientific World Journal. 1 de enero de 2019;2019:e9369051.
Etafa W, Fetensa G, Tsegaye R, Wakuma B, Sundararajan V, Bayisa G, et al. Neonatal sepsis risk factors in public hospitals in Wollega zones, Ethiopia: case control study. PAMJ - One Health [Internet]. 5 de enero de 2022 [citado 15 de abril de 2023];7(2). Disponible en: https://www.one-health.panafrican-med-journal.com/content/article/7/2/full
McGovern M, Giannoni E, Kuester H, Turner MA, van den Hoogen A, Bliss JM, et al. Challenges in developing a consensus definition of neonatal sepsis. Pediatr Res. julio de 2020;88(1):14-26.
Wattal C, Kler N, Oberoi JK, Fursule A, Kumar A, Thakur A. Neonatal Sepsis: Mortality and Morbidity in Neonatal Sepsis due to Multidrug-Resistant (MDR) Organisms: Part 1. Indian J Pediatr. 1 de febrero de 2020;87(2):117-21.
Olorukooba AA, Ifusemu WR, Ibrahim MS, Jibril MB, Amadu L, Lawal BB. Prevalence and Factors Associated with Neonatal Sepsis in a Tertiary Hospital, North West Nigeria. Niger Med J. 2020;61(2):60-6.
Megersa N, Tadesse H, Yeheyis T, Abera A, Mustefa A, Aseffa A, et al. Prevalence of neonatal sepsis and associated factors among neonates admitted in arbaminch general hospital, arbaminch, southern Ethiopia, 2019. Journal of Pediatrics & Neonatal Care. 12 de febrero de 2020;10.
Sorsa A. Epidemiology of Neonatal Sepsis and Associated Factors Implicated: Observational Study at Neonatal Intensive Care Unit of Arsi University Teaching and Referral Hospital, South East Ethiopia. Ethiopian Journal of Health Sciences [Internet]. 2019 [citado 15 de abril de 2023];29(3). Disponible en: https://www.ajol.info/index.php/ejhs/article/view/188135
Lorch SA, Rogowski J, Profit J, Phibbs CS. Access to risk-appropriate hospital care and disparities in neonatal outcomes in racial/ethnic groups and rural–urban populations. Seminars in Perinatology. 1 de junio de 2021;45(4):151409.
Murthy S, Godinho MA, Guddattu V, Lewis LES, Nair NS. Risk factors of neonatal sepsis in India: A systematic review and meta-analysis. PLOS ONE. 25 de abril de 2019;14(4):e0215683.
Al-Matary A, Heena H, AlSarheed AS, Ouda W, AlShahrani DA, Wani TA, et al. Characteristics of neonatal Sepsis at a tertiary care hospital in Saudi Arabia. Journal of Infection and Public Health. 1 de septiembre de 2019;12(5):666-72.
Ogundare E, Akintayo A, Aladekomo T, Adeyemi L, Ogunlesi T, Oyelami O. Presentation and outcomes of early and late onset neonatal sepsis in a Nigerian Hospital. African Health Sciences. 5 de noviembre de 2019;19(3):2390-9.
Palatnik A, Liu LY, Lee A, Yee LM. Predictors of early-onset neonatal sepsis or death among newborns born at <32 weeks of gestation. J Perinatol. julio de 2019;39(7):949-55.
Liu Y, Chai Y, Rong Z, Chen Y. Prognostic Value of Ionized Calcium Levels in Neonatal Sepsis. ANM. 2020;76(3):193-200.
Gebreheat G, Tadesse B, Teame H. Predictors of respiratory distress syndrome, sepsis and mortality among preterm neonates admitted to neonatal intensive care unit in northern Ethiopia. Journal of Pediatric Nursing. 1 de marzo de 2022;63:e113-20.
Ershad M, Mostafa A, Dela Cruz M, Vearrier D. Neonatal Sepsis. Curr Emerg Hosp Med Rep. 1 de septiembre de 2019;7(3):83-90.
Folgori L, Bielicki J. Future Challenges in Pediatric and Neonatal Sepsis: Emerging Pathogens and Antimicrobial Resistance. J Pediatr Intensive Care. marzo de 2019;08(1):17-24.
Salguero SMV. Características microbiológicas de sepsis neonatal. Revista Ciencia Multidisciplinaria CUNORI. 30 de agosto de 2019;3(1):85-92.
Sinnar SA, Schiff SJ. The Problem of Microbial Dark Matter in Neonatal Sepsis. Emerg Infect Dis. noviembre de 2020;26(11):2543-8.
Reyes Bernabe PA. Identificación de agentes microbiológicos de sepsis neonatal en la unidad de cuidados intensivos del Hospital General Zona Norte. septiembre de 2020 [citado 15 de abril de 2023]; Disponible en: https://repositorioinstitucional.buap.mx/handle/20.500.12371/15299
Meshram RM, Gajimwar VS, Bhongade SD. Predictors of Mortality in Outborns with Neonatal Sepsis: A Prospective Observational Study. Nigerian Postgraduate Medical Journal. diciembre de 2019;26(4):216.
Al-Matary A, Heena H, AlSarheed AS, Ouda W, AlShahrani DA, Wani TA, et al. Characteristics of neonatal Sepsis at a tertiary care hospital in Saudi Arabia. Journal of Infection and Public Health. 1 de septiembre de 2019;12(5):666-72.
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