Clinical and socio-demographic factors of type 1 diabetes in paediatric patients in a tertiary hospital in Paraguay, 2018-2021.
PDF (Español (España))

Keywords

Diabetes Mellitus, Type 1
Pediatrics
Diabetic Ketoacidosis

How to Cite

Cordone Ramos, A. M., Colmán Gómez, D. B., Cantero Noguera, C. J., & Oviedo Ramírez, S. R. (2023). Clinical and socio-demographic factors of type 1 diabetes in paediatric patients in a tertiary hospital in Paraguay, 2018-2021. Discover Medicine, 7(1). https://doi.org/10.2300/dm.v7i1.3629

Abstract

Background: Type 1 diabetes is a chronic endocrine disease of autoimmune aetiology that predominantly affects the paediatric population, and is characterised by the destruction of the insulin-producing beta cells in the pancreas

Objective: To analyse the clinical and socio-demographic factors associated with type 1 diabetes in paediatric patients treated at a tertiary hospital in Paraguay during the period 2018 to 2021.

Methodology: The study used a prospective observational design to analyse clinical and sociodemographic factors in paediatric patients with type 1 diabetes. Non-probability convenience sampling was used. Data were collected using patient charts and analysed descriptively, with ethical considerations warranted.

Results: The study included 22 paediatric patients with type 1 diabetes. Socio-demographic characteristics such as age and gender were recorded, with a mean age of 11.64 years and a female prevalence of 54.5%. Initial symptoms were varied, and ketoacidosis was present in 40.9% of cases.

Conclusion: The study achieved a detailed characterisation of clinical and socio-demographic factors in paediatric patients with type 1 diabetes in Paraguay. The results were in agreement with previous research, underlining the relevance of early identification and appropriate management in this vulnerable population. Conclusions provide a basis for educational and preventive interventions.

https://doi.org/10.2300/dm.v7i1.3629
PDF (Español (España))

References

Ilonen J, Lempainen J, Veijola R. The heterogeneous pathogenesis of type 1 diabetes mellitus. Nat Rev Endocrinol. noviembre de 2019;15(11):635-50.

Boddu SK, Aurangabadkar G, Kuchay MS. New onset diabetes, type 1 diabetes and COVID-19. Diabetes Metab Syndr Clin Res Rev. 1 de noviembre de 2020;14(6):2211-7.

Yonker LM, Neilan AM, Bartsch Y, Patel AB, Regan J, Arya P, et al. Pediatric Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Clinical Presentation, Infectivity, and Immune Responses. J Pediatr. 1 de diciembre de 2020;227:45-52.e5.

Cherubini V, Grimsmann JM, Åkesson K, Birkebæk NH, Cinek O, Dovč K, et al. Temporal trends in diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes between 2006 and 2016: results from 13 countries in three continents. Diabetologia. 1 de agosto de 2020;63(8):1530-41.

Salmi H, Heinonen S, Hästbacka J, Lääperi M, Rautiainen P, Miettinen PJ, et al. New-onset type 1 diabetes in Finnish children during the COVID-19 pandemic. Arch Dis Child. 1 de febrero de 2022;107(2):180-5.

Guo CX, He L, Yin JY, Meng XG, Tan W, Yang GP, et al. Epidemiological and clinical features of pediatric COVID-19. BMC Med. 6 de agosto de 2020;18(1):250.

Birkebaek NH, Kamrath C, Grimsmann JM, Aakesson K, Cherubini V, Dovc K, et al. Impact of the COVID-19 pandemic on long-term trends in the prevalence of diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes: an international multicentre study based on data from 13 national diabetes registries. Lancet Diabetes Endocrinol. 1 de noviembre de 2022;10(11):786-94.

Tauschmann M, Hermann JM, Freiberg C, Papsch M, Thon A, Heidtmann B, et al. Reduction in Diabetic Ketoacidosis and Severe Hypoglycemia in Pediatric Type 1 Diabetes During the First Year of Continuous Glucose Monitoring: A Multicenter Analysis of 3,553 Subjects From the DPV Registry. Diabetes Care. 22 de enero de 2020;43(3):e40-2.

Morilla L, Morel Z, Pavlicich V, Morilla L, Morel Z, Pavlicich V. Características clínicas de los pacientes pediátricos con COVID-19 en un departamento de emergencia. Pediatría Asunción. diciembre de 2020;47(3):124-31.

López JR, Pérez AT. Factores Asociados a la Diabetes en Niños de 10 Años en América Latina. Rev Científica Salud Desarro Hum. 2023;4(1):69-90.

Redondo MJ, Hagopian WA, Oram R, Steck AK, Vehik K, Weedon M, et al. The clinical consequences of heterogeneity within and between different diabetes types. Diabetologia. 1 de octubre de 2020;63(10):2040-8.

Patterson CC, Karuranga S, Salpea P, Saeedi P, Dahlquist G, Soltesz G, et al. Worldwide estimates of incidence, prevalence and mortality of type 1 diabetes in children and adolescents: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 1 de noviembre de 2019;157:107842.

Snyder LL, Stafford JM, Dabelea D, Divers J, Imperatore G, Law J, et al. Socio-economic, demographic, and clinical correlates of poor glycaemic control within insulin regimens among children with Type 1 diabetes: the SEARCH for Diabetes in Youth Study. Diabet Med. 2019;36(8):1028-36.

Goldman S, Pinhas-Hamiel O, Weinberg A, Auerbach A, German A, Haim A, et al. Alarming increase in ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes during the first wave of the COVID-19 pandemic in Israel. Pediatr Diabetes. 2022;23(1):10-8.

Al-Abdulrazzaq D, Alkandari A, Alhusaini F, Alenazi N, Gujral UP, Narayan KMV, et al. Higher rates of diabetic ketoacidosis and admission to the paediatric intensive care unit among newly diagnosed children with type 1 diabetes in Kuwait during the COVID-19 pandemic. Diabetes Metab Res Rev. 2022;38(3):e3506.

Bahendeka S, Mutungi G, Tugumisirize F, Kamugisha A, Nyangabyaki C, Wesonga R, et al. Healthcare delivery for paediatric and adolescent diabetes in low resource settings: Type 1 diabetes clinics in Uganda. Glob Public Health. 2 de diciembre de 2019;14(12):1869-83.

McGlacken-Byrne SM, Drew SEV, Turner K, Peters C, Amin R. The SARS-CoV-2 pandemic is associated with increased severity of presentation of childhood onset type 1 diabetes mellitus: A multi-centre study of the first COVID-19 wave. Diabet Med. 2021;38(9):e14640.

Winkler C, Haupt F, Heigermoser M, Zapardiel-Gonzalo J, Ohli J, Faure T, et al. Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials—GPPAD-02 study design and first results. Pediatr Diabetes. 2019;20(6):720-7.

Rabbone I, Schiaffini R, Cherubini V, Maffeis C, Scaramuzza A, Diabetes Study Group of the Italian Society for Pediatric Endocrinology and Diabetes. Has COVID-19 Delayed the Diagnosis and Worsened the Presentation of Type 1 Diabetes in Children? Diabetes Care. 10 de agosto de 2020;43(11):2870-2.

Lawrence C, Seckold R, Smart C, King BR, Howley P, Feltrin R, et al. Increased paediatric presentations of severe diabetic ketoacidosis in an Australian tertiary centre during the COVID-19 pandemic. Diabet Med. 2021;38(1):e14417.

Rugg-Gunn CEM, Dixon E, Jorgensen AL, Usher-Smith JA, Marcovecchio ML, Deakin M, et al. Factors Associated With Diabetic Ketoacidosis at Onset of Type 1 Diabetes Among Pediatric Patients: A Systematic Review. JAMA Pediatr. 1 de diciembre de 2022;176(12):1248-59.

Garg SK, Rodbard D, Hirsch IB, Forlenza GP. Managing New-Onset Type 1 Diabetes During the COVID-19 Pandemic: Challenges and Opportunities. Diabetes Technol Ther. junio de 2020;22(6):431-9.

Gregory JM, Slaughter JC, Duffus SH, Smith TJ, LeStourgeon LM, Jaser SS, et al. COVID-19 Severity Is Tripled in the Diabetes Community: A Prospective Analysis of the Pandemic’s Impact in Type 1 and Type 2 Diabetes. Diabetes Care. 2 de diciembre de 2020;44(2):526-32.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright (c) 2023 Alba María Cordone Ramos, Deisy Beatriz Colmán Gómez, Cielos Jemima Cantero Noguera, Shirley Rocío Oviedo Ramírez

Downloads

Download data is not yet available.