Toxicidad del extracto acuoso de Sida cordifolia L. mediante el ensayo de micronúcleo en ratones

Abstract

Medicinal plants are widely used in Paraguay, however most species lack scientific information on their use. It is therefore necessary to study their effects on general physiology in order to determine their possible side effects. Sida cordifolia (flannel weed), a perennial herb of the Malvaceae family, is popularly used to treat influenza, urinary infections, ovarian inflammation, as an emollient, against cooling, and anti-inflammatory activity is also described. The objective of this work was to determine the effects of the flannel weed aqueous extract on erythrocytes of the bone marrow of Mus musculus. For the genotoxicity evaluation, 2.000 erythrocytes per animal were counted; while 500 erythrocytes per animal were counted for the cytotoxicity evaluation. In the genotoxicity evaluation, at concentrations 0.01% and 0.02%, no significant results were observed; regarding the concentration of 0.04 % a level of significance was recorded compared to the negative control. In the cytotoxicity evaluation, it was observed
that all the concentrations used did not register significant results. the aqueous extract of S. cordiafolia was genotoxic at a concentration of 0.04%, but it was not cytotoxic at any of the concentrations evaluated.