Manifestaciones clínicas y laboratoriales en el Lupus Eritematoso Sistémico-LES

Autores/as

  • Isabel Acosta Colmán
  • Gabriela Avila
  • Maria Eugenia Acosta
  • Alicia Aquino
  • Osmar Centurión
  • Margarita Duarte

Palabras clave:

manifestaciones clínicas, lupus eritematoso sistémico, análisis laboratoriales

Resumen

El Lupus eritematoso sistémico (LES) es una enfermedad autoinmune compleja que se caracteriza por su capacidad de afectar a diversos órganos, lo que determina las diferentes manifestaciones clínicas objetivadas durante la evolución de la enfermedad. De forma asociada se ha descrito que estas manifestaciones presentan una variación geográfica o étnica, siendo por lo general menos grave en pacientes con ascendencia europea que en aquellos que presentan ascendencia africana, asiática o hispana. Alteraciones, tanto del sistema inmune adaptativo (células T y B) como del innato (Toll like receptorx-TLR), contribuyen al desarrollo del LES. Las células B tienen su papel en la producción de los autoanticuerpos (i.e. anticuerpos anti-ADN y anticuerpos anti-nucleosoma) y de determiandas citocinas. Las pruebas de laboratorio son de gran valor cuando se evalúa a un paciente con sospecha de enfermedad autoinmune. Los resultados pueden confirmar el diagnóstico, estimar la severidad de la enfermedad, evaluar el pronóstico y son de suma utilidad para el seguimiento de la actividad del LES.

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2016-04-01

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Acosta Colmán, I., Avila, G., Acosta, M. E., Aquino, A., Centurión, O., & Duarte, M. (2016). Manifestaciones clínicas y laboratoriales en el Lupus Eritematoso Sistémico-LES. Memorias Del Instituto De Investigaciones En Ciencias De La Salud, 14(1). Recuperado a partir de https://revistascientificas.una.py/index.php/RIIC/article/view/1850

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