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Leucemia mieloide aguda con t(8; 21)(q22; q22). Reporte de casos

Authors

  • AF Espínola Cano
  • MS Rodríguez
  • Soledad Campos
  • JA Ferreira Nizza
  • J Noguera
  • Susy Figueredo Thiel

Keywords:

leucemia mieloide, translocación genética, análisis citogenético, pronóstico

Abstract

La leucemia mieloide aguda es una neoplasia hematopoyética caracterizada por la
proliferación clonal de blastos inmaduros en médulas ósea interfiriendo con sus funciones
normales. Tiene una supervivencia aproximada de 35% afectando principalmente a
adultos mayores de 60 años y niños menores de un año y preferentemente al sexo
masculino. Un hallazgo frecuente es la presencia de la translocación cromosómica t (8;
21) (q22; q22) que involucra a los genes RUNX1 y RUNX1T1. La detección de esta
alteración tiene implicancia diagnóstica y pronóstica de la enfermedad. El objetivo de este
trabajo es describir y reportar dos casos de leucemia mieloide aguda en pacientes
masculinos de 14 y 24 años que presentaron clínica, laboratorio y morfología típicos de la
enfermedad pero con edad de aparición no habitual, enfatizando además, el pronóstico
bueno desde el punto de vista citogenético de esta translocación en ambos casos.

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References

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Published

2011-12-01

Issue

Vol. 9 No. 2 (2011): Julio-Diciembre

Section

Case report

How to Cite

Espínola Cano, A., Rodríguez, M., Campos, S., Ferreira Nizza, J., Noguera, J., & Figueredo Thiel, S. (2011). Leucemia mieloide aguda con t(8; 21)(q22; q22). Reporte de casos. Memorias Del Instituto De Investigaciones En Ciencias De La Salud, 9(2). https://revistascientificas.una.py/index.php/RIIC/article/view/1720