La fragmentación del complejo QRS del electrocardiograma y su correlación con alteraciones cardiovasculares
DOI:
https://doi.org/10.18004/mem.iics/1812-9528/2024.e22142401Palabras clave:
Complejo QRS fragmentado, electrocardiograma, cardiopatía isquémica, síndrome coronario agudoResumen
La presencia de complejos QRS fragmentados (fQRS) en un electrocardiograma (ECG) de 12 derivaciones de rutina es un marcador interesante de anormalidad de la despolarización. El fQRS representa un retraso en la conducción debido a una activación no homogénea de los ventrículos debido a una cicatriz miocárdica. Sin embargo, la fQRS no es específica de la enfermedad de las arterias coronarias y además se encuentra en otras enfermedades del miocardio como la miocardiopatía y la cardiopatía congénita. fQRS también se há descrito en otras entidades como la miocardiopatía arritmogénica del ventrículo derecho y el síndrome de Brugada. La importancia y el valor predictivo del complejo fQRS como marcador ECG de eventos cardiovasculares parecen ser diferentes en diferentes entidades. En pacientes con enfermedad arterial coronaria estable y en pacientes con infarto de miocardio agudo, la fQRS parece ser un buen predictor de eventos cardíacos. En pacientes con miocardiopatía no isquémica, la fQRS estrecho parece correlacionarse con el grado de fibrosis y disincronía, y podría influir en la respuesta a la terapia de resincronización cardíaca. En pacientes con disfunción del VI, no hay evidencia clara de que la presencia de fQRS pueda predecir eventos arrítmicos. Por otro lado, hubo diferencia estadísticamente significativa en la mortalidad asociada a la presencia de fQRS en pacientes con síndrome coronario agudo y necrosis miocárdica. La presencia de fQRS, posee una alta especificidad y un alto valor predictivo positivo debido a la existencia de trastornos segmentarios de la motilidad miocárdica en pacientes con cardiopatía isquémica.
Descargas
Citas
Montalescot G, Sechtem U, Achenbach S, Andreotti F, Arden C, Budaj A, et al. ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J 2013; 34 (38): 2949-3003. 10.1093/EURHEARTJ/EHT296 .
Luqman N, Sung RJ, Wang CL, Kuo CT. Myocardial ischemia and ventricular fibrillation: pathophysiology and clinical implications. Int J Cardiol 2007; 119(3): 283-90. 10.1016/j.ijcard.2006.09.016
Prystowsky EN. Primary prevention of sudden cardiac death: the time of your life. Circulation. 2004; 109 (9): 1073-5. 10.1161/01.CIR.0000121314.13795.F1
Zipes DP, Camm AJ, Borggrefe M, Buxton AE, Chaitman B, Fromer M, et al. ACC/AHA/ ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: a report of the American College of Car-diology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (writing committee to develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation 2006; 114(10): e385-484. 10.1161/CIRCULATIONAHA.106.178233
Huikuri HV, Castellanos A, Myerburg RJ. Sudden death due to cardiac arrhythmias. N Engl J Med 2001; 345 (20): 1473-82. 10.1056/NEJMra000650
Torales JM, Centurión OA, Aquino NJ, Chávez CO, Alderete JF, Scavenius KE, et al. The relation between QRS complex fragmentation and segmental abnormalities of the myocardial contractility in patients with coronary artery disease. Indian Heart Journal 2021; 73(3): 325-30. 10.1016/j.ihj.2021.03.010
Aquino NJ, Centurión OA, Torales JM, Miño LM, Scavenius KE, Alderete JF, et al. Association of QRS Complex Fragmentation with QT Interval Prolongation in Patients with Ischemic Heart Disease. Curr Health Sci J 2019 Oct-Dec; 45(4): 398-404. 10.12865/CHSJ.45.04.08
Qaddoura A, Digby G C, Kabali C, Kukla P, Tse G, Glover B, Baranchuk AM. Use of fragmented QRS in prognosticating clinical deterioration and mortality in pulmonary embolism: A meta-analysis. Ann Noninvasive Electrocardiol. 2018 Sep; 23 (5): e12552. 10.1111/anec.12552 owers NC, Horan LG, Thomas JR, Tolleson WJ, et al. (1969). The anatomic basis for high-frequency components in the electrocardiogram. Circulation.1969; 39(4): 531-9. 10.1161/01.cir.39.4.531
García-Escobar A, Vera-Vera S, Jurado-Román A, Jiménez-Valero S, Galeote G, Moreno R. Subtle QRS changes are associated with reduced ejection fraction, diastolic dysfunction, and heart failure development and therapy responsiveness: Applications for artificial intelligence to ECG. Annals of Noninvasive Electrocardiology, 2022; 27: e12998. 10.1111/anec.12998
Meng L, Letsas KP, Baranchuk A, Shao Q, Tse G, Zhang N, et al. Meta-analysis of Fragmented QRS as an Electrocardiographic Predictor for Arrhythmic Events in Patients with Brugada Syndrome. Front Physiol. 2017; 12(8): 678. doi: 10.3389/fphys.2017.00678
Agbaedeng TA, Roberts KA, Colley L, Noubiap JJ, Oxborough D. Incidence and predictors of sudden cardiac death in arrhythmogenic right ventricular cardiomyopathy: a pooled analysis. Europace. 2022; 24: 1665-1674. 10.1093/europace/euac014.
Hasdemir C, Sahin H, Duran G, Orman MN, Kocabas U, Payzin S. Electrocardiographic variables associated with underlying Brugada syndrome or drug-induced Type 1 Brugada pattern in patients with slow/fast atrioventricular nodal reentrant tachycardia. J Arrhythmia. 2022; 38: 633-41. 10.1002/joa3.12729
Xie J, Liu Y, Wei X, Ye W, Ma Z, Lu G, et al. Relationship Between Fragmented QRS Complex and Left Ventricular Fibrosis and Function in Patients With Danon Disease. Front. Cardiovasc. Med. 2022: 9: 790917. 10.3389/fcvm.2022.790917
Gardner PI, Ursell PC, Fenoglio JJ Jr, Wit AL. Electrophysiologic and anatomic basis for fractionated electrograms recorded from healed myocardial infarcts. Circulation. 1985; 72 (3): 596-611. 10.1161/01.cir.72.3.596
Das MK, Khan B, Jacob S, Kumar A, Mahenthiran J. Significance of a fragmented QRS complex versus a Q wave in patients with coronary artery disease. Circulation. 2006;113(21): 2495-501. 10.1161/CIRCULATIONAHA.105.595892
Das MK, Suradi H, Maskoun W, Michael MA, Changyu Shen, Peng J, et al. Fragmented wide QRS on a 12-lead ECG: A sign of myocardial scar and poor prognosis. Circ Arrhythm Electrophysiol. 2008; 1(4): 258-68. 10.1161/CIRCEP.107.763284
Das MK, Saha C, El Masry H, Peng J, Dandamudi G, Mahenthiran J, et al. Fragmented QRS on a 12-lead ECG: a predictor of mortality and cardiac events in patients with coronary artery disease. Heart Rhythm. 2007; 4(11): 1385-92. 10.1016/j.hrthm.2007.06.024
Kohli P, Cannon CP. Acute coronary syndromes in 2011: walking the tight rope between efficacy and bleeding. Nat Rev Cardiol. 2011; 9(2): 69-71. 10.1038/nrcardio.2011.206
Fuster V, Lewis A. Mechanisms leading to myocardial infarction: Insights from studies of vascular biology. Circulation. 1994; 90(4): 2126-46. 10.1161/01.cir.90.4.2126
Falk E, Shah PK, Fuster V. Coronary plaque disruption. Circulation. 1995; 92(3): 657-71. 10.1161/01.cir.92.3.657
Rogers WJ, Frederick PD, Stoehr E, Canto JG, Ornato JP, Gibson CM, et al. Trends in presenting characteristics and hospital mortality among patients with ST elevation and non-ST elevation myocardial infarction in the National Registry of Myocardial Infarction from 1990 to 2006. Am Heart J. 2008; 156(6): 1026-34. 10.1016/j.ahj.2008.07.030
Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K, et al. Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009; 119(3): e21-181. 10.1161/CIRCULATIONAHA.108.191261
Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, et al. Executive summary: heart disease and stroke statistics--2010 update: a report from the American Heart Association. Circulation. 2010; 121 (7): e46-e215. 10.1161/CIRCULATIONAHA.109.192667
Ferreira-González I. Epidemiología de la enfermedad coronaria. Rev Esp Cardiol. 2014; 67(2): 139-44. 10.1016/j.recesp.2013.10.003
Lerner DJ, Kannel WB. Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population. Am Heart J. 1986; 111(2): 383-90. 10.1016/0002-8703(86)90155-9
Gordon T, Kannel WB, Hjortland MC, McNamara PM. Menopause and coronary heart disease. The Framingham Study. Ann Intern Med. 1978; 89: 157-61. 10.7326/0003-4819-89-2-157
Kannel WB. Common electrocardiographic markers for subsequent clinical coronary events. Circulation. 1987; 75 (3 Pt 2): II25-7.
Taylor GJ, Humphries JO, Mellits ED, Pitt B, Schulze RA, Griffith LSC, et al. Predictors of clinical course, coronary anatomy and left ventricular function after recovery from acute myocardial infarction. Circulation 1980; 62: 960-70. 10.1161/01.cir.62.5.960
Adabag AS, Therneau TM, Gersh BJ, et al. Sudden death after myocardial infarction. JAMA 2008; 300: 2022-2029. 10.1001/jama.2008.553
Moss AJ, Hall WJ, Cannom DS, et al. Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. Multicenter Automatic Defibrillator Implantation Trial Investigators. N Engl J Med 1996; 335: 1933-40. 10.1056/NEJM199612263352601
Moss AJ, Zareba W, Hall WJ, Klein H, Wilber D, Cannom DS, et al. for the Multicenter Automatic Defibrillator Implantation Trial II Investigators. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med. 2002; 346: 877-83. 10.1056/NEJMoa013474
Buxton AE, Lee KL, Fisher JD, et al. A randomized study of the prevention of sudden death in patients with coronary artery disease. Multicenter Unsustained Tachycardia Trial Investigators. N Engl J Med 1999; 341: 1882-90. 10.1056/NEJM199912163412503
Moss AJ, Zareba W, Hall WJ, et al. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med 2002; 346: 877-83. 10.1056/NEJMoa013474
Sourour N, Riveland E, Rømo T, Næsgaard P, Kjekshus H, Larsen AI, et al. QRS fragmentation is associated with increased risk of ventricular arrhythmias in high-risk patients; Data from the SMASH 1 Study. Annals of Noninvasive Electrocardiology, 2022: 27, e12985. 10.1111/anec.12985
Akbarzadeh F, Pourafkari L, Ghaffari S, Hashemi M, Sadeghi-Bazargani H. Predictive value of the fragmented QRS complex in 6 month mortality and morbidity following acute coronary syndrome. Int J Gen Med. 2013 May 28; 6: 399-404. 10.2147/IJGM.S40050
Das MK, Zipes DP. Fragmented QRS: a predictor of mortality and sudden cardiac death. Heart Rhythm 2009; 6(3): S8-S14. 10.1016/j.hrthm.2008.10.019
Das MK, Saha C, El Masry H, Peng J, Dandamudi G, Mahenthiran J, et al. Fragmented QRS on a 12-lead ECG: a predictor of mortality and cardiac events in patients with coronary artery disease. Heart Rhythm 2007; 4(11):1385-92. 10.1016/j.hrthm.2007.06.024
Pietrasik G, Goldenberg I, Zdzienicka J, Moss AJ, Zareba W. Prognostic Significance of Fragmented QRS Complex for Predicting the Risk of Recurrent Cardiac Events in Patients With Q-Wave Myocardial Infarction. Am J Cardiol 2007; 100(4): 583-586. 10.1016/j.amjcard.2007.03.063
Das MK, Michael MA, Suradi H, Peng J, Sinha A, Shen C, et al. Usefulness of Fragmented QRS on a 12-Lead Electrocardiogram in Acute Coronary Syndrome for Predicting Mortality. Am J Cardiol 2009; 104(12):1631-7. 10.1016/j.amjcard.2009.07.046
Kalra V, Konakondla P, Clary JM, Das MK. Fragmented QRS predicts mortality in patients with systolic heart failure. JACC 2010; 55(10s1): A1. E8-A1.
Das MK, Zipes DP. Role of the fragmented QRS complexes on a routine 12-lead ECG in predicting mortality and sudden cardiac death. Rev. Argent. Cardiol 2010; 78: 5-10.
Das MK, Khan B, Jacob S, Kumar A, Mahenthiran J. Significance of a Fragmented QRS Complex Versus a Q Wave in Patients with Coronary Artery Disease. Circulation 2006; 113: 2495-501. 10.1161/CIRCULATIONAHA.105.595892
Pietrasik G, Zareba W: QRS Fragmentation: Diagnostic and prognostic significance. Cardiol J, 2012, 19(2): 114-21. 10.5603/cj.2012.0022
Michael MA, Das MK. Fragmented QRS on a 12-lead ECG is a Sign of Acute or Recent Myocardial Infarction. Circulation 2006; 114: II 512.
Das MK, Michael MA, Suradi H. Fragmented QRS Complex on 12-lead ECG Developed During the First 48 Hours after Acute Myocardial Infarction Predicts Mortality. Circulation 2008; 118: S 1059.
Das MK, Maskoun W, Shen C, Michael MA, Suradi H, Desai M, et al. Fragmented QRS on twelve-lead electrocardiogram predicts arrhythmic events in patients with ischemic and nonischemic cardiomyopathy. Heart Rhythm 2010; 7(1): 74-80. 10.1016/j.hrthm.2009.09.065
Yildirim E, et al. The relationship between fragmentation on electrocardiography and in-hospital prognosis of patients with acute myocardial infarction. Med Sci Monit, 2014; 20: 913-19. 10.12659/MSM.890201.
Çanga A, Kocaman S, et al. Relationship between fragmented QRS complexes and left ventricular systolic and diastolic functions. Herz 2013; 38: 665. 10.1007/s00059-012-3739
Korhonen P, Husa T, et al. Fragmented QRS in prediction of cardiac deaths and heart failure hospitalizations after myocardial infarction. Ann Noninvasive Electrocardiol. 2010 Apr; 15(2): 130-7. 10.1111/j.1542-474x.2010.003653.x.
Kadi H, Ceyhan K, Koç F, Celik A, et al. Relation between fragmented QRS and collateral circulation in patients with chronic total occlusion without prior myo-cardial infarction. Anadolu Kardiyol Derg. 2011; 11(4): 300-4.
Wang DD, Buerkel DM, Corbett JR, Gurm HS, et al. Fragmented QRS complex has poor sensitivity in detecting myocardial scar. Ann Noninvasive Electrocardiol. 2010; 15 (4): 308-14. 10.1111/j.1542-474X.2010.00385.x
Carey MG, Luisi AJ Jr, Baldwa S, Al-Zaiti S, et al. The Selvester QRS Score is more accurate than Q waves and fragmented QRS complexes using the Mason-Likar configuration in estimating infarct volume in patients with ischemic cardiomyopathy. J Electrocardiol. 2010; 43: 318-25. 10.1016/j.jelectrocard.2010.02.011
Allescher J, Sinnecker D, von Goeldel B, et al. QRS fragmentation does not predict mortality in survivors of acute myocardial infarction. Clin Cardiol. 2024; 47: e24218. 10.1002/clc.24218
Zangiabadian M, Sharifian Ardestani M, Rezaee M, et al. Fragmented QRS, a strong predictor of mortality and major arrhythmic events in patients with nonischemic cardiomyopathy: a systematic review and meta-analysis. Health Sci Rep. 2024;7: e1888. 10.1002/hsr2.1888
Morillas Climent H, et al. Fragmentación del complejo QRS en pacientes con Miocardiopatía Dilatada y Cardiopatía Isquémica: Diferencias básicas. Rev Esp Cardiol. 2013;66 Supl 1: 1018.
García M, et al. Complejo QRS fragmentado. Utilidad como predictor de riesgo cardiovascular y correlación con trastornos regionales de motilidad y anatomía coronaria. Insuf Card 2013; 8(1): 2-8.
Yan G, Wang M, Zhi G, Yiu KH, Lau CP, Lee SW, et al. Subclinical Left Ventricular Dysfunction Revealed by Circumferential 2D Strain Imaging in Coronary Artery Disease Patients with ECG Fragmented QRS Complex. Circulation 2011; 124: A15016.
Michael MA, Das MK. Fragmented QRS on a 12-lead ECG is a Sign of Acute or Recent Myocardial Infarction. Circulation 2006;114: II 512.
Das MK, Michael MA, Suradi H. Fragmented QRS Complex on 12-lead ECG Developed During the First 48 Hours after Acute Myocardial Infarction Predicts Mortality. Circulation 2008; 118: S 1059.
Morita H, Kusano KF, Miura D, Nagase S, Nakamura K, Morita ST, et al. Fragmented QRS as a marker of conduction abnormality and a predictor of prognosis of Brugada syndrome. Circulation 2008; 118: 1697e1704.
Sakane K, Takaki H, Okamura H. Visualization of intra-QRS fragmented activation in patients with hypertrophic cardiomyopathy and life-threatening ventricular arrhythmia using magnetocardiography. Eur Heart J, 2011;32 (Suppl.1): 155.
Centurión, O. A. (2021). Wide QRS Complex and Left Ventricular Lateral Repolarization Abnormality: The Importance of ECG Markers on Outcome Prediction in Patients with COVID-19. The American Journal of the Medical Sciences, 362(1), 1-2. 10.1016/J.AMJMS.2021.04.005.
Stavileci B, Özdemir E, Özdemir B, Ereren E, Cengiz M. De-novo development of fragmented QRS during a six-month follow-up period in patients with COVID-19 disease and its cardiac effects. J Electrocardiol 2022; 72: 44-8. 10.1016/j.jelectrocard.2022.02.012
Laredo M, Tovia-Brodie O, Milman A, Michowitz Y, Roudijk RW, Peretto G. Electrocardiographic findings in patients with arrhythmogenic cardiomyopathy and right bundle branch block ventricular tachycardia. 10.1093/europace/euac267
Vecchiato M, Quinto G, Borasio N, Palermi S Berton G, Battista F. The Fragmented QRS Complex in Lead V1: Time for an Update of the Athlete's ECG? J Cardiovasc Translation Res 2023; 17: 24-32.