Actividad sinérgica in vitro de los alcaloides Crotsparina y Esparsiflorina aislados de Croton bomplandianum frente a Pseudomonas aeruginosa

Javier García; Nelson Alvarenga

Autores/as

Javier García Universidad Nacional de Asunción, Facultad de Ciencias Química, Departamento de Fitoquímica, Dirección de Investigación. San Lorenzo, Paraguay
Nelson Alvarenga Universidad Nacional de Asunción, Facultad de Ciencias Química, Departamento de Fitoquímica, Dirección de Investigación. San Lorenzo, Paraguay

Palabras clave:

crotsparina, esparsiflorina, Croton, Pseudomonas, gentamicina, ciprofloxacina

Resumen

Se evaluó la actividad sinérgica de los alcaloides crotsparina y esparsiflorina, aislados de Croton bomplandianum Baill. con los antibacterianos gentamicina y ciprofloxacina frente a Pseudomonas aeruginosa, microorganismo frecuentemente responsable de infecciones intrahospitalarias. Se empleó el método del “tablero de damas”. Se encontraron combinaciones que presentaban efecto sinérgico, logrando la reducción de 87,5% de la CMI de gentamicina, mientras que para ciprofloxacina se logró una reducción del 25,0%. Esto abre interesantes perspectivas sobre el uso combinado de productos naturales puros y fármacos en uso clínico para el tratamiento de infecciones producidas por este microrganismo.

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