Retrospective analysis of the incidence of cardiovascular events in patients with chronic kidney disease and type 2 diabetes in a tertiary hospital in Paraguay, 2020- 2021
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Keywords

Renal Insufficiency
Diabetes Mellitus
Cardiovascular Diseases

How to Cite

Torres Romero, A. D. (2023). Retrospective analysis of the incidence of cardiovascular events in patients with chronic kidney disease and type 2 diabetes in a tertiary hospital in Paraguay, 2020- 2021. Discover Medicine, 7(1). https://doi.org/10.2300/dm.v7i1.3627

Abstract

Background: Chronic kidney disease (CKD) and type 2 diabetes (DM2) are two highly prevalent pathologies worldwide that represent a major public health challenge. These conditions carry a significantly elevated risk of adverse cardiovascular events,
such as myocardial infarction, stroke and cardiovascular death.
Materials and methods: The design is observational, descriptive and retrospective of cardiovascular events in patients with chronic kidney disease (CKD) and type 2 diabetes (DM2) who were treated at the Hospital de Clínicas del Paraguay. Data were obtained from the complete medical records of the hospitalised patients.
Results: A total of 14 medical records were reviewed, of which 10 corresponded to the year 2020 and 4 to the year 2021. The mean age of the patients included in the study was 62.14 years. Among the most frequent reasons for consultation, lower limb injuries were the most common, being the reason for consultation in 6 (42.86%) patients. Five (35.71%) cardiovascular events were observed in the study population.
Conclusion: These findings highlight the importance of comprehensive care and constant monitoring of cardiovascular risk factors in patients with CKD and DM2, with the aim of preventing and adequately managing cardiovascular events associated with these chronic diseases.

https://doi.org/10.2300/dm.v7i1.3627
PDF (Español (España))

References

Carney EF. The impact of chronic kidney disease on global health. Nat Rev Nephrol. mayo de 2020;16(5):251-251.

Khunti S, Khunti K, Seidu S. Therapeutic inertia in type 2 diabetes: prevalence, causes, consequences and methods to overcome inertia. Ther Adv Endocrinol Metab. 1 de enero de 2019;10:2042018819844694.

Pitt B, Filippatos G, Agarwal R, Anker SD, Bakris GL, Rossing P, et al. Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes. N Engl J Med. 9 de diciembre de 2021;385(24):2252-63.

Yamazaki T, Mimura I, Tanaka T, Nangaku M. Treatment of Diabetic Kidney Disease: Current and Future. Diabetes Metab J. 22 de enero de 2021;45(1):11-26.

Ricciardi CA, Gnudi L. Kidney disease in diabetes: From mechanisms to clinical presentation and treatment strategies. Metabolism. 1 de noviembre de 2021;124:154890.

Chagnac A, Zingerman B, Rozen-Zvi B, Herman-Edelstein M. Consequences of Glomerular Hyperfiltration: The Role of Physical Forces in the Pathogenesis of Chronic Kidney Disease in Diabetes and Obesity. Nephron. 4 de abril de 2019;143(1):38-42.

Jager KJ, Kovesdy C, Langham R, Rosenberg M, Jha V, Zoccali C. A single number for advocacy and communication—worldwide more than 850 million individuals have kidney diseases. Nephrol Dial Transplant. 1 de noviembre de 2019;34(11):1803-5.

Standl E, Khunti K, Hansen TB, Schnell O. The global epidemics of diabetes in the 21st century: Current situation and perspectives. Eur J Prev Cardiol. 1 de diciembre de 2019;26(2_suppl):7-14.

Avilés-Santa ML, Monroig-Rivera A, Soto-Soto A, Lindberg NM. Current State of Diabetes Mellitus Prevalence, Awareness, Treatment, and Control in Latin America: Challenges and Innovative Solutions to Improve Health Outcomes Across the Continent. Curr Diab Rep. 10 de octubre de 2020;20(11):62.

Redmon JH, Levine KE, Lebov J, Harrington J, Kondash AJ. A comparative review: Chronic Kidney Disease of unknown etiology (CKDu) research conducted in Latin America versus Asia. Environ Res. 1 de enero de 2021;192:110270.

Wheeler DC, Stefánsson BV, Jongs N, Chertow GM, Greene T, Hou FF, et al. Effects of dapagliflozin on major adverse kidney and cardiovascular events in patients with diabetic and non-diabetic chronic kidney disease: a prespecified analysis from the DAPA-CKD trial. Lancet Diabetes Endocrinol. 1 de enero de 2021;9(1):22-31.

Peralta R, Gamarra Fleitas F, Gómez Fernández MN, Vaesken Rojas J, Frutos López RD, Galeano Vera SM, et al. Características clínicas de la anemia en la enfermedad renal crónica de pacientes del Hospital Nacional en 2018. Rev Virtual Soc Paraguaya Med Interna. marzo de 2019;6(1):11-20.

Rico Fontalvo J, Vázquez Jiménez LC, Rodríguez Yánez T, Daza Arnedo R, Raad Sarabia M, Montejo Hernández JD, et al. Enfermedad renal diabética: puesta al día. An Fac Cienc Médicas Asunción. diciembre de 2022;55(3):86-98.

Duan J, Wang C, Liu D, Qiao Y, Pan S, Jiang D, et al. Prevalence and risk factors of chronic kidney disease and diabetic kidney disease in Chinese rural residents: a cross-sectional survey. Sci Rep. 18 de julio de 2019;9(1):10408.

Thomas B. The Global Burden of Diabetic Kidney Disease: Time Trends and Gender Gaps. Curr Diab Rep. 2 de marzo de 2019;19(4):18.

Giandalia A, Giuffrida AE, Gembillo G, Cucinotta D, Squadrito G, Santoro D, et al. Gender Differences in Diabetic Kidney Disease: Focus on Hormonal, Genetic and Clinical Factors. Int J Mol Sci. enero de 2021;22(11):5808.

Jankowski J, Floege J, Fliser D, Böhm M, Marx N. Cardiovascular Disease in Chronic Kidney Disease. Circulation. 16 de marzo de 2021;143(11):1157-72.

Sarnak MJ, Amann K, Bangalore S, Cavalcante JL, Charytan DM, Craig JC, et al. Chronic Kidney Disease and Coronary Artery Disease. J Am Coll Cardiol. 8 de octubre de 2019;74(14):1823-38.

Hong T, Su Q, Li X, Shan Z, Chen L, Peng Y, et al. Glucose-lowering pharmacotherapies in Chinese adults with type 2 diabetes and cardiovascular disease or chronic kidney disease. An expert consensus reported by the Chinese Diabetes Society and the Chinese Society of Endocrinology. Diabetes Metab Res Rev. 2021;37(4):e3416.

Ammirati AL. Chronic Kidney Disease. Rev Assoc Médica Bras. 13 de enero de 2020;66:s03-9.

Wang B, Li R, Lu Z, Huang Y. Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis. Aging. 8 de abril de 2020;12(7):6049-57.

Smilowitz NR, Bhandari N, Berger JS. Chronic kidney disease and outcomes of lower extremity revascularization for peripheral artery disease. Atherosclerosis. 1 de marzo de 2020;297:149-56.

Prasad A, Hughston H, Michalek J, Trevino A, Gupta K, Martinez JP, et al. Acute kidney injury in patients undergoing endovascular therapy for critical limb ischemia. Catheter Cardiovasc Interv. 2019;94(4):636-41.

Lv JC, Zhang LX. Prevalence and Disease Burden of Chronic Kidney Disease. En: Liu BC, Lan HY, Lv LL, editores. Renal Fibrosis: Mechanisms and Therapies [Internet]. Singapore: Springer; 2019 [citado 11 de agosto de 2023]. p. 3-15. (Advances in Experimental Medicine and Biology). Disponible en: https://doi.org/10.1007/978-981-13-8871-2_1

Qassim M, Al-Musawi H, Al-saadi A. AGE AND GENDER IMPACT ON GLYCAEMIC CONTROL, RENAL FUNCTION AND OXIDATIVE STRESS PARAMETERS IN IRAQI PATIENTS TYPE 2 DIABETES MELLITUS. Biochem Cell Arch. 17 de abril de 2021;21:491-9.

Ekun OA, Fagbemi OF, Adejumo EN, Ekun OO, Wojuade KS, Oshundun FM, et al. Assessment of electrolytes, markers of glycaemic control and renal dysfunction among adult Nigerians recently diagnosed with type 2 diabetes mellitus. Afr Health Sci. 28 de octubre de 2022;22(3):296-306.

Su WY, Chen SC, Huang YT, Huang JC, Wu PY, Hsu WH, et al. Comparison of the Effects of Fasting Glucose, Hemoglobin A1c, and Triglyceride–Glucose Index on Cardiovascular Events in Type 2 Diabetes Mellitus. Nutrients. noviembre de 2019;11(11):2838.

Sacerdote A, Dave P, Lokshin V, Bahtiyar G. Type 2 Diabetes Mellitus, Insulin Resistance, and Vitamin D. Curr Diab Rep. 10 de septiembre de 2019;19(10):101.

Zhang Q, Wu Y, Lu Y, Fei X. Eficacia y seguridad de la metformina y de los inhibidores del cotransportador-2 de sodio-glucosa en adultos con diabetes tipo 1: una revisión sistemática y metaanálisis en red. Rev Clínica Esp. 1 de enero de 2020;220(1):8-21.

Bugiardini R, Yoon J, Kedev S, Stankovic G, Vasiljevic Z, Miličić D, et al. Prior Beta-Blocker Therapy for Hypertension and Sex-Based Differences in Heart Failure Among Patients With Incident Coronary Heart Disease. Hypertension. septiembre de 2020;76(3):819-26.

Cespón Fernández M. Uso de los IECA y ARA-II en el síndrome coronario agudo con FEVI conservada en la era del intervencionismo coronario percutáneo. 2022 [citado 11 de agosto de 2023]; Disponible en: https://minerva.usc.es/xmlui/handle/10347/28838

Salmeri E, Elbert A, Lavalle-Cobo A, Aranguren F, Sanabria H, Giorgi M, et al. Association between cardiovascular disease and kidney disease in a sample of real-world diabetes patients. Arch Cardiol México. junio de 2022;92(2):165-73.

Mullens W, Damman K, Harjola VP, Mebazaa A, Brunner-La Rocca HP, Martens P, et al. The use of diuretics in heart failure with congestion — a position statement from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2019;21(2):137-55.

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Copyright (c) 2023 Anthon Daniel Torres Romero

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