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Memorias del Instituto de Investigaciones en Ciencias de la Salud (Mem. Inst. Investig. Cienc. Salud) is the official publication of the Institute of Research in Health Sciences (IICS) of the National University of Asunción (UNA), Paraguay. It publishes original scientific contributions in clinical medicine, biomedical research, microbiology, molecular biology, dentistry, nursing, nutrition, public health, health biotechnology, genetics, biochemistry, and related disciplines. Founded in 1983, the journal adopted its current name in 2002 and has been published exclusively online since 2015, incorporating XML article dissemination as of 2024. Since 2023, it operates under a continuous publication model. The journal accepts manuscripts in Spanish and English as original research articles, reviews, case studies, and brief communications. All content is available in open access, free of charge for authors and readers, under the Creative Commons Attribution 4.0 International License, in accordance with the Budapest Open Access Initiative (BOAI). It is indexed in BVS, SciELO Paraguay, HINARI, LILACS, DOAJ, Latindex, MIAR, Dialnet, CiteFactor, Google Scholar, LivRe, BASE, EBSCO, and Web of Science – SciELO Citation Index. The journal is funded by IICS-UNA, supports the OAI-PMH protocol for metadata harvesting, and uses the LOCKSS system for digital preservation of its contents.

 
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Manuscripts submitted to Memorias del Instituto de Investigaciones en Ciencias de la Salud undergo a double-blind peer review process, in which the identities of both authors and reviewers remain anonymous throughout the evaluation. Each manuscript is assessed by a minimum of two external reviewers with expertise in the relevant subject area, who are given a period of 30 days to submit their evaluation. Reviewers assess the originality, methodological rigor, scientific relevance, and clarity of presentation of each work. Based on the reviewers' reports, the Editorial Committee decides whether to accept, request revisions, or reject the manuscript, and communicates the decision to the authors as promptly as possible. This process ensures impartiality, transparency, and the scientific quality of published articles.

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The Institute of Research in Health Sciences (IICS) of the National University of Asunción (UNA) invites researchers, academics, and health professionals to submit their manuscripts for consideration in the 2026 Volume of Memorias del Instituto de Investigaciones en Ciencias de la Salud (Mem. Inst. Investig. Cienc. Salud). The journal accepts original and unpublished contributions in Spanish as original research articles, review articles, case studies, and brief communications, in the areas of clinical medicine, biomedical research, microbiology, molecular biology, dentistry, nursing, nutrition, public health, health biotechnology, genetics, biochemistry, and related disciplines. The call for submissions is open and ongoing, and manuscripts may be submitted at any time of the year through the journal's online submission system. All received manuscripts undergo double-blind peer review. The journal is open access, with no charges for authors or readers. For further information on submission guidelines, please refer to the author instructions available on the journal's website.

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Comorbid insomnia and obstructive sleep apnea (COMISA) with bruxism and periodic limb movements

Authors

DOI:

https://doi.org/10.18004/mem.iics/1812-9528/2026.e24132601

Keywords:

Sleep apnea, insomnia, sleeps quality

Abstract

A clinical case of COMISA (combined insomnia and obstructive sleep apnea disorder) is presented, along with bruxism and periodic limb movements. The diagnostic and therapeutic complexity of this condition is highlighted through the use of clinical tools and polysomnography. Findings show sleep fragmentation, severe hypoxia, and abnormal muscle activity. A multidisciplinary management approach is proposed, including weight loss, CPAP, and cognitive-behavioral therapy. The high prevalence of sleep disorders in Latin American countries is emphasized, as well as the bidirectional relationship between insomnia and OSA, and the importance of identifying comorbidities. Finally, the need for a multidisciplinary approach is underscored, as these disorders are associated with cardiovascular risk, depression, and reduced productivity.

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References

1. Pavlova MK, Latreille V. Sleep Disorders. Am J Med. 2019;132(3):292-299. 10.1016/j.amjmed.2018.09.021.

2. Sweetman A, Osman A, Lack L, Crawford M, Wallace D. Co-morbid insomnia and sleep apnea (COMISA): recent research and future directions. Curr Opin Pulm Med. 2023; 29(6): 567-573. 10.1097/MCP.0000000000001007.

3. Sweetman AM, Lack LC, Catcheside PG, Antic NA, Chai-Coetzer CL, Smith SS et al. Developing a successful treatment for co-morbid insomnia and sleep apnoea. Sleep Med Rev. 2017; 33: 28-38. 10.1016/j.smrv.2016.04.004.

4. Lobbezoo F, Ahlberg J, Raphael KG, Wetselaar P, Glaros AG, Kato T et al. International consensus on the assessment of bruxism. J Oral Rehabil. 2018;45(11):837-844. 10.1111/joor.12663.

5. Kuang B, Li D, Lobbezoo F, de Vries R, Hilgevoord A, de Vries N et al. Associations between sleep bruxism and other sleep-related disorders in adults. Sleep Med. 2022; 89: 31-47. 10.1016/j.sleep.2021.11.008.

6. Drakatos P, Olaithe M, Verma D, Ilic K, Cash D, Fatima Y et al. Periodic limb movements during sleep: a narrative review. J Thorac Dis. 2021; 13(11): 6476-6494. 10.21037/jtd-21-1353.

7. Torterolo P, Benedetto L, Copiz N, Peyrou S. Calidad de sueño en Uruguay al inicio de la pandemia. Ann Facultad Med (UnivRepùbUrug). 2023; 10(2): e201. 10.25184/anfamed2023v10n2a1.

8. Castro LS, Poyares D, Leger D, Bittencourt L, Tufik S. Objective prevalence of insomnia in the São Paulo, Brazil epidemiologic sleep study. Ann Neurol. 2013;74(4):537-46. 10.1002/ana.23945.

9. Tufik S, Santos-Silva R, Taddei JA, Bittencourt LR. Obstructive sleep apnea syndrome in the Sao Paulo Epidemiologic Sleep Study. Sleep Med. 2010;11(5):441-446. 10.1016/j.sleep.2009.10.005.

10. Luciano YM, Porcacchia AS, Tufik S, Andersen ML, Pires GN. Prevalence and Incidence of Co-Morbid Insomnia and Sleep Apnea (Comisa) in São Paulo, Brazil. Chest. 2024;165(4):1004-1008. 10.1016/j.chest.2023.11.024.

11. Sweetman A, Frank O, Stocks N, Mukherjee S, Lack L. General practitioner management of comorbid insomnia and sleep apnoea. Aust J Gen Pract. 2023;52(9):607-612. 10.31128/AJGP-12-22-6648.

12. Hoc TV, Lee HC. Clinical and polysomnographic characteristics of Asian patients with comorbid insomnia and obstructive sleep apnea. Sci Rep. 2025;15(1):11529. 10.1038/s41598-025-96825-7.

13. Sweetman A. Co-morbid Insomnia and Sleep Apnoea (COMISA): Latest Research from an Emerging Field. Curr Sleep Medicine Rep. 2023;9:180-189. 10.1007/s40675-023-00262-9.

14. Krystal AD, Prather AA, Ashbrook LH. The assessment and management of insomnia: an update. World Psychiatry. 2019;18(3):337-352. 10.1002/wps.20674.

15. Wulterkens BM, Hermans LWA, Fonseca P, Asin J, Duis N, Janssen HCJP et al. Sleep structure in patients with COMISA compared to OSA and insomnia. J Clin Sleep Med. 2023;19(6):1051-1059. 10.5664/jcsm.10500.

16. Ma Y, Goldstein MR, Davis RB, Yeh GY. Profile of subjective-objective sleep discrepancy in patients with insomnia and sleep apnea. J Clin Sleep Med. 2021;17(11):2155-2163. 10.5664/jcsm.9348.

17. Yanagimori M, Fernandes MD, Garcia ML, Scudeller PG, Carvalho CRR, Edwards B et al. Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA). Sci Rep. 2023;13(1):7638. 10.1038/s41598-023-34002-4.

18. Shi Y, Feng X, Hao F, Nie Y, Zhang Y, Ren R et al. Clinical subtypes of co-morbid insomnia and obstructive sleep apnea (COMISA): Results of a cluster analysis. SSRN Electronic Journal: april, 2025. 10.2139/ssrn.5212284.

19. Kuang B, Li D, Lobbezoo F, de Vries R, Hilgevoord A, de Vries N et al. Associations between sleep bruxism and other sleep-related disorders in adults. Sleep Med. 2022;89:31-47. 10.1016/j.sleep.2021.11.008.

20. Blaszczyk B, Meira E, Cruz M, Waliszewska-Prosol M, Wieckiewicz M, Nowacki D et al. Sleep Bruxism and Sleep Structure in COMISA Syndrome: A Polysomnographic Study. J Clin Med. 2024;13(11):3154. 10.3390/jcm13113154.

21. Subramanian S, Hesselbacher SE, Nye P, Aiyer AA, Surani SR. Comorbid insomnia and sleep apnea: characterization and associations with comorbid sleep conditions. Sleep Breath. 2021;25(4):1995-2000. 10.1007/s11325-021-02331-1.

22. Zhou X, Zhou B, Li Z, Lu Q, Li S, Pu Z et al. Periodic limb movements in patients with obstructive sleep apnea syndrome. Sci Rep. 2021;11(1):15341. 10.1038/s41598-021-95018-2.

23. Suzuki K, Suzuki S, Haruyama Y, Funakoshi K, Fujita H, Sakuramoto H et al. Associations between the burdens of comorbid sleep problems, central sensitization, and headache-related disability in patients with migraine. Front Neurol. 2024;15:1373574. 10.3389/fneur.2024.1373574.

24. Sweetman A, Farrell S, Wallace DM, Crawford M. The effect of cognitive behavioural therapy for insomnia in people with comorbid insomnia and sleep apnoea: A systematic review and meta-analysis. J Sleep Res. 2023;32(6):e13847. 10.1111/jsr.13847.

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Published

2026-02-12

Issue

Section

Case report

How to Cite

Perez Bejarano, D. (2026). Comorbid insomnia and obstructive sleep apnea (COMISA) with bruxism and periodic limb movements. Memorias Del Instituto De Investigaciones En Ciencias De La Salud, 24(1), e24132601. https://doi.org/10.18004/mem.iics/1812-9528/2026.e24132601