Our day-to-day at Memorias del IICS

A glimpse into our day-to-day at the Memorias del IICS office

Leer más

About

Memorias del Instituto de Investigaciones en Ciencias de la Salud (Mem. Inst. Investig. Cienc. Salud) is the official publication of the Institute of Research in Health Sciences (IICS) of the National University of Asunción (UNA), Paraguay. It publishes original scientific contributions in clinical medicine, biomedical research, microbiology, molecular biology, dentistry, nursing, nutrition, public health, health biotechnology, genetics, biochemistry, and related disciplines. Founded in 1983, the journal adopted its current name in 2002 and has been published exclusively online since 2015, incorporating XML article dissemination as of 2024. Since 2023, it operates under a continuous publication model. The journal accepts manuscripts in Spanish and English as original research articles, reviews, case studies, and brief communications. All content is available in open access, free of charge for authors and readers, under the Creative Commons Attribution 4.0 International License, in accordance with the Budapest Open Access Initiative (BOAI). It is indexed in BVS, SciELO Paraguay, HINARI, LILACS, DOAJ, Latindex, MIAR, Dialnet, CiteFactor, Google Scholar, LivRe, BASE, EBSCO, and Web of Science – SciELO Citation Index. The journal is funded by IICS-UNA, supports the OAI-PMH protocol for metadata harvesting, and uses the LOCKSS system for digital preservation of its contents.

 
Leer más

Peer Review Process

Manuscripts submitted to Memorias del Instituto de Investigaciones en Ciencias de la Salud undergo a double-blind peer review process, in which the identities of both authors and reviewers remain anonymous throughout the evaluation. Each manuscript is assessed by a minimum of two external reviewers with expertise in the relevant subject area, who are given a period of 30 days to submit their evaluation. Reviewers assess the originality, methodological rigor, scientific relevance, and clarity of presentation of each work. Based on the reviewers' reports, the Editorial Committee decides whether to accept, request revisions, or reject the manuscript, and communicates the decision to the authors as promptly as possible. This process ensures impartiality, transparency, and the scientific quality of published articles.

Leer más

Call for Papers

The Institute of Research in Health Sciences (IICS) of the National University of Asunción (UNA) invites researchers, academics, and health professionals to submit their manuscripts for consideration in the 2026 Volume of Memorias del Instituto de Investigaciones en Ciencias de la Salud (Mem. Inst. Investig. Cienc. Salud). The journal accepts original and unpublished contributions in Spanish as original research articles, review articles, case studies, and brief communications, in the areas of clinical medicine, biomedical research, microbiology, molecular biology, dentistry, nursing, nutrition, public health, health biotechnology, genetics, biochemistry, and related disciplines. The call for submissions is open and ongoing, and manuscripts may be submitted at any time of the year through the journal's online submission system. All received manuscripts undergo double-blind peer review. The journal is open access, with no charges for authors or readers. For further information on submission guidelines, please refer to the author instructions available on the journal's website.

Leer más

Paciente joven con disfonía: un caso de amiloidosis poco habitual

Authors

  • Alicia Maria Aquino Valdovinos
  • Maria Isabel Acosta Colmán
  • Hugo Boggino Author
  • Margarita Duarte Mussi de Laterza Author

Keywords:

amiloidosis sistémica, disfonía, laringe

Abstract

La amiloidosis es una enfermedad caracterizada por el depósito extracelular de fibrillas compuestas por subunidades de bajo peso molecular de una variedad de proteínas. Puede ser clasificada según su distribución y según la proteina fibrilar constituyente. La prevalencia varía según el área geográfica estudiada y el pronóstico depende del tejido u órgano afectado. Presentamos el caso de un varón jóven con disfonía de larga evolución sin otros síntomas acompañantes en cuya nasofibroscopía se observaron una tumoración en regíon laríngea. En la anatomía patológica se observó material hialino
congofílico compatible con amiloide. Se realizó además una biopsia rectal donde también se observó material amiloide. Debido a la poca sintomatología y a la ausencia de compromiso de un órgano que comprometa la vida, en este paciente se optó por un manejo conservador.

Downloads

Download data is not yet available.

References

Sipe JD, Benson MD, Buxbaum JN, Ikeda S, Merlini G, Saraiva MJ, et al. Amyloid fibril proteinnomenclature: 2012 recommendations from the Nomenclature Committee of the International Society of Amyloidosis. Amyloid. 2012 Dec;19(4):167-70.

Westermark P, Benson MD, Buxbaum JN, Cohen AS, Frangione B, Ikeda S, et al. A primer of amyloid nomenclature. Amyloid. 2007 Sep;14(3):179-83.

Nomenclature of amyloid and amyloidosis. WHO-IUIS Nomenclature Sub-Committee. Bull World Health Organ 1993;71(1):105-12.

Kyle RA, Linos A, Beard CM, Linke RP, Gertz MA, O'Fallon WM, Kurland LT. Incidence and natural history of primary systemic

amyloidosis in Olmsted County, Minnesota, 1950 through 1989. Blood. 1992;79(7):1817-22.

Merlini G, Palladini G. Amyloidosis: Is a cure possible?. Ann Oncol. 2008;19(4):63-6.

Kurita N, Kotera N, Ishimoto Y, Tanaka M, Tanaka S, Toda N, et al. AA amyloid nephropathy with predominant vascular

deposition in Crohn's disease. Clin Nephrol. 2013;79(3):229-32.

Shin SC, Robinson-Papp J. Amyloid neuropathies. Mt Sinai J Med. 2012;79(6):733-48.

Sattianayagam P, Hawkins P, Gillmore J. Amyloid and the GI tract.1. Expert Rev Gastroenterol Hepatol. 2009;3(6):615-30.

Yood RA, Skinner M, Rubinow A, Talarico L, Cohen AS. Bleeding manifestations in 100 patients with amyloidosis. JAMA. 1983;249 (10):1322-4.

Vázquez de la Iglesia F, Sánchez Ferrándis N, Rey Martínez J, Ruba San Miguel D, Rama López J, Fernández González S. Amyloidosis in the ORL field. Acta Otorrinolaringol Esp.

;57(3):145-8.

Raymond AK, Sneige N, Batsakis JG. Amyloidosis in the upper aerodigestive tracts. Ann Otol Rhinol Laryngol. 1992;101(9):794-6.

Thompson LD, Derringe GA, Wenig BM. Amyloidosis of the Larynx: A clinico pathologic study of 11 cases. Mod Pathol. 2000;13 (5):528–35.

Lewis JE, Olsen KD, Kurtin PJ, Kyle RA. Laryngeal amyloidosis: A clinico pathologic and immunohistochemical review. Otolaryngol Head Neck Surg. 1992; 106( 4):372-7.

Yiotakis I, Georgolios A, Charalabopoulos A, Hatzipantelis P, Golias C, Charalabopoulos K, Manolopoulos L. Primary localized laryngeal amyloidosis presenting with hoarseness and

dysphagia: A case report. Journal of Medical Case Report. 2009; 3:9049.

Westermark P, Davey E, Lindbom K, Enqvist S. Subcutaneous fat tissue for diagnosis and studies of systemic amyloidosis. Acta Histochem. 2006;108(3):209-13.

Van Gameren II, Hazenberg BP, Bijzet J, van Rijswijk MH. Diagnostic accuracy of subcutaneous abdominal fat tissue aspiration for detecting systemic amyloidosis and its

utility in clinical practice. Arthritis Rheum. 2006;54(6):2015-21.

Dhingra S, Krishnani N, Kumari N, Pandey R. Evaluation of abdominal fat pad aspiration cytology and grading for detection in systemic amyloidosis. Acta Cytol. 2007;51(6):860-4.

Herlenius G, Wilczek HE, Larsson M, Ericzon BG, Familial Amyloidotic Polyneuropathy World Transplant Registry. Ten years of international experience with liver transplantation for familial amyloidotic polyneuropathy: results from the Familial

Amyloidotic Polyneuropathy World Transplant Registry. Transplantation. 2004;77(1):64-71.

Tsuchiya A, Yazaki M, Kametani F, Takei Y, Ikeda S. Marked regression of abdominal fat amyloid in patients with familial amyloid polyneuropathy during long-term follow-up after liver transplantation. Liver Transpl. 2008;14(4):563-70.

Benson MD. Liver transplantation and transthyretin amyloidosis. Muscle Nerve 2013; 47 (2):157-62.

Yamamoto S, Wilczek HE, Nowak G, Larsson M, Oksanen A, Iwata T, et al. Liver transplantation for familial amyloidotic

polyneuropathy (FAP): Asingle-center experience over 16 years. Am J Transplant. 2007;7(11):2597-604.

Nelson LM, Penninga L, Sander K, Hansen PB, Villadsen GE, Rasmussen A, Gustafsson F. Long-term outcome in patients treated with combined heart and liver transplantation for familial amyloidotic cardiomyopathy. Clin Transplant. 2013;27

(2):203-9.

Downloads

Published

2015-08-01

Issue

Vol. 13 No. 2 (2015): Mayo-Agosto

Section

Case report

How to Cite

Aquino Valdovinos, A. M., Boggino, H., & Duarte Mussi de Laterza, M. (2015). Paciente joven con disfonía: un caso de amiloidosis poco habitual. Memorias Del Instituto De Investigaciones En Ciencias De La Salud, 13(2). https://revistascientificas.una.py/index.php/RIIC/article/view/1817