Clinics features and complications in patients receiving mechanical ventilation in the adults intensive care unit of the Hospital de Clínicas
DOI:
https://doi.org/10.18004/Keywords:
mechanical ventilation, complications, pneumonia, ParaguayAbstract
Objectives: to determine the frequency, clinical features, complications and factors associated with mortality of patients on mechanical ventilation. Materials and Methods: retrospective, descriptive with an analytical component of patients admitted to the Adult Intensive Care Unit of the Clinical Hospital, between January 2001 and May 2002. Clinical records were used and analyzed using Epi Info version 3.5.1., significant p <0.05. Results: Of 715 patients admitted, we evaluated 511 that required mechanical ventilation (71.5%). Most common indications for mechanical ventilation: postoperative 43.2% (n = 211), lung disease 23% (n = 117), neurological 7.4% (n = 38). Average duration of mechanical ventilation: 7.7 ± 9 days. Tracheostomy was performed in 7.6% (n = 39) of patients, more frequently indicated for prolonged intubation 40.6% (n = 13), on average on day 17; of these 87.1% (n = 34) were discharged with tracheostomy. Extubation failure: 10.4% (n = 53) and the most common causes were: poor secretions management and poor respiratory mechanics 17% (n = 9). Overall mortality was 52.6% (n = 269). Most common complications: pneumonia 31.7% (n = 53), mechanical complications related to the endotracheal tube 16.2% (n = 27), atelectasis 12% (n = 20), self-extubation 9% (n = 15), tracheostomy complications 7.8% (n = 13). Overall mortality in patients with complications related to mechanical ventilation was 49.7% (n = 83) and mortality attributable to complications of mechanical ventilation was 34.9% (n = 29). The complication most frequently associated with death was pneumonia (p = 0.03). Conclusion: use of mechanical ventilation is common, with significant associated complications, of which pneumonia is the main one and with the worst prognosis.
References
1. Tobin, Martin J. Current Concepts: Mechanical Ventilation. The New England Journal of
Medicine. 1994; 330(15): 1056-61.
2. Tobin, Martin J. Medical Progress: Advances in Mechanical Ventilation. The New England
Journal of Medicine. 2001; 344(26): 1986-96.
3. Sandur S; Stoller JK. Pulmonary complications of mechanical ventilation. Clin Chest Med.
1999; 20(2): 223-47.
4. Auriant I, Reignier J, Pibarot M L. Critical incidents related to invasive mechanical ventilation
in the ICU: preliminary descriptive study. Intensive Care Medicine 2002; 28:452-8.
5. Frutos-Vivar F, Esteban A, Apeslegia C. Outcome of mechanically ventilated patients who
require a tracheostomy. Critical Care Medicine 2004; 33: 290-8.
6. Esteban A, Anzueto A, Frutos F. Characteristics and Outcomes in Adult Patients Receiving
Mechanical Ventilation: A 28-Day International Study. JAMA 2002; 287(3): 345-55.
7. Esteban A, Anzueto A, Alia I. How is mechanical employed in the intensive care unit. Am J.
Respir Crut Care Med 2000; 161(5): 1450-8.
8. Chonabayashi N, Aoshima M. Mechanical ventilation and long term respiratory care the
intensive care unit of a general hospital. Nihon Kyobu Shikkan Gakkaai Zasshi 1995; 33: 159-
67.
9. Mutlu G M, Mutlu E A, Factor P D. GI Complications in Patients Receiving Mechanical
Ventilation. Chest 2001; 119(4): 1222-41.
10. Epstein Scott K, Ciubotaru Ronald L, Wong John B. Effect of Failed Extubation on the
Outcome of Mechanical Ventilation. Chest 1997;112(1): 186-92.
11. Ovid Esteban, Intesive Care Unit (ICU) Mortality in Ventilated Patients. JAMA 2002;
287(3):345-55.
12. Warren D K, Shukla S J. Outcome and Attributable Cost of Ventilator-Associated Pneumonia
Among Intensive Care Unit Patients in a Suburban Medical Center. Critical Care Medicine
2003; 31(5):1312-17.
13. Ely, E W, Evans Gregory W. Mechanical Ventilation in a cohort of Elderly Patients Admitted to
an Intensive Care Unit. Annals of Internal Medicine 1999; 131(2)96-104.
14. Engoren, M, Buderer, N F, Zacharias A. Long-term survival and health status after prolonged
mechanical ventilation after cardiac surgery. Critical Care Medicine 2000; 28(8):2742-49.
15. Knaus WA, Draper EA, Wagner DP, Zimmerman JE: APACHE II: a severity of disease
classification system. Crit Care Med 1985; 13:818-29.
16. Le Gall JR, Loirat P, Alperovitch A, Glaser P, Granthil C, Mathieu D, Mercier P, Thomas R,
Villers D: A simplified acute physiology score for ICU patients. Crit Care Med 1984; 12:975-77.
17. Ayub K, Báez S, Bianco H, Ayala C, Figueredo B, Villafañe M. Bacteriemia Nosocomial en
Unidad de Cuidados Intensivos de Adultos del Hospital de Clínicas. Clínicas 2003; 7(1): 54-
18. Báez S, Yanes L, Bianco H, Ayala C, Figueredo B, Villafañe M. Infecciones Nosocomiales a
Bacilos Gram Negativos en Unidad de Cuidados Intensivos de Adultos. Clínicas 2002; 6(2):
44-53.
19. Silvestre W, Goldsmith D, Uchino S. Percutaneous Versus Surgical Tracheostomy: A
Randomized Controlled Study With Long-Term Follow-Up. Crit Care Med 2006;34(8):2145-52.
20. Dulguerov P, Gysin C, Perneger TV, et al: Percutaneous or surgical tracheostomy: A metaanalysis.
Crit Care Med 1999; 27:1617-25.
21. Freeman BD, Isabella K, Lin N, et al: A meta-analysis of prospective trials comparing
percutaneous and surgical tracheostomy in critically ill patients. Chest 2000; 118:1412-18.
22. Cheng E, Fee WE: Dilatational versus standard tracheostomy: A meta-analysis. Ann Otol
Rhinol Laryngol 2000; 109:803-7.
23. Fagon JY, Chastre J, Novara A, Medioni P, Gibert C. Characterization of intensive care unit
patients using a model based on the presence or absence of organ dysfunctions and/or
infection. The ODIN method. Intensive Care Med 1993; 19: 137-44.

