Mucormicosis rhinocerebral - Communication of 4 cases
DOI:
https://doi.org/10.18004/Keywords:
Mucormycosis, mucormycosis in diabetes, rhino-cerebral mucormycosis, ParaguayAbstract
The mucormycosis is a rare infection, with high morbidity and mortality; produced by opportunistic fungi of the order Mucorales belonging to several families and species. This infection presents several clinical forms. The most common is the rhino-cerebral. Predisposing factors are many but the principals are decompensated diabetes mellitus and leukemia. We report four cases of rhino-cerebral mucormycosis related to diabetes mellitus; three of them with fatal evolution. In all cases, we found both in the mycological study and in the pathological anatomy the characteristics of hyaline hyphae with right-angled branches. Particularly, in two cases, the culture identified Rhizopus spp and Mycoclades spp as responsible.
References
1. Arenas R. Zigomicosis. En: Arenas R. Micología médica ilustrada. 4ta ed. China: McGraw Hill; 2011. p. 251-268.
2. Spelberg B., Ibrahim A. Mucormicosis. En: Longo D, Fauci A, Kasper D, Hauser S, Jameson J, Loscalzo J. Harrison. Principios de medicina interna. 18 ed. China: Mc Graw-Hill; 2012. p. 1661-1664.
3. Nieto J, Moreno L, Zapata A., Ocampo C. Arbey A., Serna L. et al. Tratamiento exitoso de mucormicosis rino-orbito-cerebral en un paciente trasplantado renal. Nefrología. 2014; 34(1): 120-4.
4. Tiraboschi I, Bravo M., Fernandez N, Stecher D Melero M, Lasala M. Mucormicosis. Una micosis emergente. Medicina (Buenos Aires) 2012; 72: 23-27.
5. Curutchet D. Zigomicosis. Rev argent dermatol. (online). 2010; 91(2) (citado 2015-09-22), pp. 00-00. Disponible en: http://www.scielo.org.ar/scielo.php
6. Artal R, Ágreda B, Serrano E, Alfonso J, Vallés H. Mucormicosis rinocerebral: a propósito de 8 casos. Acta Otorrinolaringol. Esp 2010; 61(4): 301–305
7. Longley B. Enfermedades micóticas. En: Elder D, Elenitsas R, Jaworsky C, Johnson B. Lever - Histopatología de la piel. 8 ed. Buenos Aires: Inter-Médica; 1999. p. 461-490
8. Piette W. Cutaneous Manifestations of Microvascular Occlusion Syndromes. In: Bolognia J, Jorizzo J, Schaffer J. Dermatology. 3ra ed. China: Elsevier; 2012. p. 369-384.
9. Arreaza F, Sabino D, Hurtado M, Castro H, Zerpa M, Contreras L. Zigomicosis rino – cerebral aguda por Rhizopus arrhizus. Med Cután Iber Lat Am 2001; 29(6): 364-368.
10. Álvarez M, Sánchez L, Hernández G, Zafra P, Socorro S. Mucormicosis rinocerebral. Informe de un caso atípico. DermatologíaCMQ 2005; 3(3): 272-275.
11. Gamaletsou M, Sipsas N, Roilides E, Walsh T. Rhino-orbital-cerebral mucormycosis. Curr Infect Dis Rep 2012; 14 (4):423-34
12. McCarthy M, Rosengart A, Schuetz A, Kontoyiannis D, Walsh T. Mold Infections of the Central Nervous System. N Engl J Med 2014; 371: 150-160
13. Spellberg B, Walsh T, Kontoyiannis D, Edwards J, Ibrahim A. Recent advances in the management of mucormycosis: from bench to bedside. Clin Infect Dis 2009; 48: 1743-51.
