Sensitivity profile of Escherichia coli isolated from urinary tract infections of patients of the Regional Hospital of Villarrica from July 2013 to August 2015
DOI:
https://doi.org/10.18004/anales/2019.052(02)17-022Keywords:
Urinary tract infection, Sensitivity Profile, Escherichia coli, Extended Spectrum Betalactamase, ESBL, ParaguayAbstract
Introduction: The inappropriate use of antimicrobials is leading to a decrease in the antimicrobial sensitivity of microorganisms that cause infectious diseases. The clinical use of antimicrobials has been parallel to the emergence of bacteria resistant to its action. Materials and methods: The sensitivity profile of Escherichia coli isolated from patients with urinary tract infections (UTI) concurrent to the Regional Hospital of Villarrica in the period from 2013 to 2015 was determined. Results: Ampicillin showed a resistance of 100%, ciprofloxacin showed a sensitivity of 73%. Amikacin showed a sensitivity of 100% and gentamicin 82%. The family of carbapenem showed a sensitivity of 100%. Within the group of nitrofurans a sensitivity of 96% was found. Trimethoprim / sulfamethoxazole had a sensitivity of 57%. The presence of Extended Spectrum Beta Lactamase (ESBL) was determined in 13% of the strains of Escherichia coli studied. Conclusions: Gentamicin, nitrofurantoin and carbapenem have a high sensitivity, so in the presence of strains with ESBL they would be feasible options always accompanied by the evaluation of the renal profile and classifying the UTI as complicated or not.
References
1. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348(16):1546-54.
2. Arnold JJ, Hehn LE, Klein DA. Common Questions About Recurrent Urinary Tract Infections in Women. Am Fam Physician. 2016;93(7):560-9.
3. Schaeffer AJ, Nicolle LE. Urinary Tract Infections in Older Men. N Engl J Med. 2016;374(22):2192.
4. Pigrau C. Nocosomial urinary tract infections. Enferm Infecc Microbiol Clin. 2013;31(9):614-24.
5. Pastor-Sánchez, R. Alteraciones del nicho ecológico: resistencias bacterianas a los antibióticos. Gac Sanit. 2006;20(Supl 1):175-81.
6. Carmeli Y, Akova M, Cornaglia G, Daikos GL, Garau J, Harbarth S, Rossolini GM, Souli M, Giamarellou H. Controlling the spread of carbapenemase-producing Gram-negatives: therapeutic approach and infection control. Clin Microbiol Infect. 2010;16(2):102-11.
7. Nordmann P, Dortet L, Poirel L. Carbapenem resistance in Enterobacteriaceae: Here is the storm! Trends Mol Med. 2012;18(5):263-72.
8. Qureshi ZA, Paterson DL, Potoski BA, Kilayko MC, Sandovsky G, Sordillo E et al. Treatment outcome of bacteremia due to KPC-producing Klebsiella pneumoniae: superiority of combination antimicrobial regimens. Antimicrob Agents Chemother. 2012;56(4):2108-13.
9. Michael L. Wilson Loretta Gaido,Laboratory Diagnosis of Urinary Tract Infections in Adult Patients Clinical Infectious Diseases, Volume 38, Issue 8, 15 April 2004, Pages 1150–1158.
10. Bauer AW, Kirby WM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966;45(4):493-6.
11. Clinical and Laboratory Standards Institute Performance Standards for Antimicrobial Susceptibility Testing: Twenty-first Informational Supplement M100-S21 2015Wayne, PA, USA CLSI. In: https://clsi.org Ultima visita: Enero 2019.
12. Machado JE, Murillo MM. Evaluación de sensibilidad antibiótica en urocultivos de pacientes en primer nivel de atención en salud de Pereira. Rev Salud Pública 2012; 14(4): 710-9.
13. Gómez CP, Plata M, Sejnaui J, Rico CL, Vanegas S. Resistencia de la E.coli en urocultivos de pacientes con sospecha de infección urinaria intra y extrahospitalaria en la Fundación Santa Fe de Bogotá. Urol Colomb. 2009; 18(1): 53-8.
14. Leguizamón M., Samudio M., Aguilar G., Sensibilidad antimicrobiana de enterobacterias aisladas en infecciones urinarias de pacientes ambulatorios y hospitalizados del Hospital Central del IPS. Mem. Inst. Investig. Cienc. Salud. 2017; 15(3): 41-49.
15. Melgarejo L., Walder A., Ovando F., Velázquez G., Chirico C., Santa Cruz F., Susceptibilidad in vitro a los antibióticos de bacterias productoras de infecciones urinarias en la mujer: Evaluación retrospectiva de 5 años, Rev Nefrol Dial Traspl. 2017; 37 (2): 96-103.
16. Nagai M., Alvarez M., Torales J., Frecuencia de Agentes Bacterianos y su Perfil de Sensibilidad en Urocultivos Procesados en el Laboratorio Central de Salud Pública en el 2010. Rev. Inst. Med. Trop. 2011;6 (Suplemento); Noviembre 2011.
17. Chirico M, Sotomayor V, Britez S, Genes M, Benitez S, Paravicini E. Etiología de las Infecciones Urinarias en Menores de 3 Meses. Rev. Inst. Med. Trop. 2011;6(Suplemento): 35-36.
18. Aguinaga A, Gil-Setas A, Mazón Ramos A, Alvaro A, García-Irure JJ, Navascués A, Ezpeleta Baquedano C. Uncomplicated urinary tract infections. Antimicrobial susceptibility study in Navarre. An Sist Sanit Navar. 2018;41(1):17-26.

