Nuclear expression of the HER2 oncogene in epithelial ovarian cancer
DOI:
https://doi.org/10.18004/mem.iics/1812-9528/2025.e23122506Keywords:
Oncogene, HER2, ovarian, cancerAbstract
The HER2 oncogene has been implicated in the pathogenesis of ovarian cancer and may serve as both a prognostic biomarker and a therapeutic target. This study aimed to analyze the nuclear expression of HER2 in ovarian cancer and benign tumor samples collected at a public hospital in Argentina between 2021 and 2024, using immunohistochemistry. Nuclear HER2 expression was observed in 26% of samples as strongly positive (3+), 20% as moderately positive (2+), and the remaining samples as negative. In contrast, HER2 expression in the cytoplasmic membrane was minimal and largely inconclusive. A significantly higher frequency of nuclear HER2 was found in malignant tumors compared to benign ones (p<0.05). These findings suggest that nuclear HER2 may play a role in tumor progression and could serve as a potential biomarker for diagnosis and prognosis in ovarian cancer, although these initial conclusions will need to be confirmed with subsequent studies.
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