Skin sensitization to aero-allergens in children with rhinitis and asthma
Keywords:
asthma, allergic rhinitis, skin sensitivity test, aeroallergensAbstract
Introduction: Allergic diseases are very common in the pediatric population. Among the frequent causes are aeroallergens from the environment and the identification of these is a great help for diagnosis and treatment. Objectives: To determine the frequency of aeroallergens, through the determination of Immunoglobulin E (IgE) specific to common allergens by the skin sensitivity test in pediatric patients with symptoms of asthma and allergic rhinitis. Materials and Methods: Observational, descriptive, prospective, cross-sectional design, population of patients from 4 to 17 years old with symptoms compatible with asthma and allergic rhinitis who attended a pediatric care center during the study period. It was carried out by means of Skin Puncture Tests (PCP). Results: The mean age of the patients was 8 years, 57% male patients and 43% female. 53% of the patients presented Rhinitis and Asthma, 45% only Rhinitis and 2% only Asthma. 79% of the patients presented a positive allergic sensitization reaction through PCP. Taking into account the sensitization by type of aeroallergens, 64% of the patients had a positive reaction to mites, 19 % to animals 18% to cockroaches, 8% to pollens and 6% to fungi. Conclusion: The vast majority of patients with asthma suffered from concomitant allergic rhinitis and dust mites were the most frequently determined aeroallergens in allergic skin tests in children with asthma and rhinitis in our population.
Downloads
References
Eigenmann P a, Atanaskovic-Markovic M, O’B Hourihane J, Lack G, Lau S, Matricardi PM, et al. Testing children for allergies: why, how, who and when: an updated statement of the European Academy of Allergy and Clinical Immunology (EAACI) Section on Pediatrics and the EAACI-Clemens von Pirquet Foundation. Pediatr Allergy Immunol [Internet]. 2013 Mar [cited 2014 Aug 28]; 24(2):195–209. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23506293
Asher I, Montefort S, Björkstén B, Lai CKW, Strachan DP, Weiland SK, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys [Internet]. Vol. 368, www.thelancet.com. 2006 [cited 2019 May 19]. Available from: www.thelancet.com
World Allergy Organization. WAO White Book on Allergy [Internet]. Pawankar R, Canonica G., Holgate S., R.F L, editor , WI: World Allergy. 2011 Available from: https://wao.confex.com/wao/2011wac/webprogram/Handout/Paper2271/WAO White Book on Allergy. Pawankar.pdf
Lambrecht BN, Hammad H. The immunology of asthma. Nature Immunology. 2015; 16.
Larenas-Linnemann D, Luna-Pech JA, Rodríguez-Pérez N, Rodríguez-González M, Arias-Cruz A, Blandón-Vijil MV, et al.Guía Mexicana de Inmunoterapia. Guía de diagnóstico de alergia mediada por IgE e inmunoterapia aplicando el método ADAPTE [GUIMIT 2019, Mexican Guideline on Immunotherapy. Guideline on the diagnosis of IgE-mediated allergic disease and immunotherapy following the ADAPTE approach]. Rev Alerg Mex. 2019;66 Suppl 1:1-105. Spanish. doi: 10.29262/ram.v66i5.631. PMID: 31200597.
Papadopoulos NG, Arakawa H, Carlsen K-H, Custovic A, Gern J, Lemanske R, et al. International consensus on (ICON) pediatric asthma. Allergy [Internet]. 2012 Aug [cited 2019 May 19];67(8):976–97. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22702533
Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention [Internet]. Fontana: GINA; 2019 [citado el 26 de noviembre de 2019]. Disponible en: https://ginasthma.org/2018-gina-report-global-strategy-for-asthma-management-and-prevention/
Eiringhaus K, Renz H, Matricardi P, Skevaki C. Component-Resolved Diagnosis in Allergic Rhinitis and Asthma. J Appl Lab Med. 2019 Mar;3(5):883-898. doi: 10.1373/jalm.2018.026526. Epub 2018 Nov 12. PMID: 31639763.
Scadding GK, Kariyawasam HH, Scadding G, Mirakian R, Buckley RJ, Dixon T, et al. BSACI guideline for the diagnosis and management of allergic and non-allergic rhinitis (Revised Edition 2017; First edition 2007). ClinExp Allergy. 2017;47(7):856–89.
Custovic A, de Moira AP, Murray CS, Simpson A. Environmental influences on childhood asthma: Allergens. Pediatr Allergy Immunol. 2023 Feb;34(2):e13915. doi: 10.1111/pai.13915. PMID: 3682574
García-Gomero D, López-Talledo MDC, Galván-Calle C, Muñoz-León R, Matos-Benavides E, Toribio-Dionicio C, et al. Sensibilización a aeroalérgenos en una población pediátrica peruana con enfermedades alérgicas. Rev Peru Med Exp Salud Publica. 2020;37(1):57-62. Doi: https://doi.org/10.17843/rpmesp.2020.371.4460
Sonia T, Meriem M, Yacine O, Nozha BS, Nadia M, Bechir L, et al. Prevalence of asthma and rhinitis in a Tunisian population. Clin Respir J. 2018;12(2):608-15.
Mallol J, Raby P, Cambiazo D, Peñaloza C, Palma R, De Orúe M. Prevalencia y perfil de sensibilización a aeroalérgenos en 1.199 niños asmáticos: Serie consecutiva de casos. Rev Med Chil. 2014; 142(5):567–73
Alcalá-Padilla G, Bedolla-Barajas M, Kestler-Gramajo A, Valdez-López F. Prevalencias de sensibilización a alergenos en niños escolares con asma que viven en la zona metropolitana de Guadalajara. Rev Alerg Méx. 2016;63(2):135-142. Disponible en: http://revistaalergia.mx/ojs/index.php/ram/article/view/184/302
Aggarwal P, Senthilkumaran S. Dust Mite Allergy. 2023 Aug 8. In: StatPearls . Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 32809553.
Ronchetti R, Rennerova Z, Barreto M, Villa MP. The prevalence of atopy in asthmatic children correlates strictly with the prevalence of atopy among nonasthmatic children. Int Arch Allergy Immunol 2007; 142 (1): 79-85
Narváez-Gómez EI. Prevalencia de sensibilización a aeroalérgenos en pacientes con rinitis alérgica en el sur de Bolivia. Vaccimonitor. 2016;25(2):49-54.
Rodríguez Santos O, Feres A, Khair, Oswaldo I, Morán T, Celio murillo R, et al. Pruebas cutáneas de punción con extractos estandarizados de ácaros de diferente procedencia en pacientes con asma y rinitis alérgica. Rev Alerg México. 2010;57(6):196-201.
Sposato B, Liccardi G, Russo M, Folletti I, Siracusa A, Scichilone N, et al. Cypress pollen: an unexpected major sensitizing agent in different regions of Italy. J Investig Allergol Clin Immunol. 2014; 24(1):23-8.
Pefura-Yone EW, Afane-Ze E, Kuaban C. Sensibilisation à Blomia tropicalis chez les patients asthmatiques à Yaoundé, Cameroun. Rev Mal Respir. 2015; 32(1):24-9.
Sakashita M, Hirota T, Harada M, Nakamichi R, Tsunoda T, Osawa Y, et al. Prevalence of allergic rhinitis and sensitization to common aeroallergens in a Japanese population. Int Arch Allergy Immunol. 2010; 151(3):255-61.
Velasco-Medina AA, Velázquez-Sámano G. Sensibilización al polen de Casuarina equisetifolia y Pinus spp en pacientes con rinitis alérgica y asma en la Ciudad de México. Rev Alerg México. 2014;61(1):9-13.
Assarehzadegan M-A, Shakurnia A, Amini A. The most common aeroallergens in a tropical region in Southwestern Iran. World Allergy Organ J. 4 de abril de 2013;6(1):7.
González-Díaz SN, Arias-Cruz A, Ibarra-Chávez JA, Elizondo-Villarreal B, Rivero-Arias DM, Salinas-Díaz MDR. Prevalencia de sensibilización a hongos en pacientes con alergia respiratoria. Rev Alerg México. 2016; 63(2):143.
Pendino P, Agüero C, Cavagnero P, Lopez K, Kriunis I, Molinas J. Aeroallergen Sensitization in Wheezing Children From Rosario, Argentina. World Allergy Organ J. 2011;4(10):159-63.
Herrera-Castro DA, Arias-Cruz A, González-Díaz SN, Hernández-Robles M, Galindo-Rodríguez G, Macías-Weinmann A, et al. Sensibilización al gato en pacientes con alergia respiratoria. Experiencia de una institución universitaria. Med Univ. 2010; 12(48):165-70.
Sánchez J, Diez S, Cardona R. Frecuencia de sensibilización a animales en un área tropical. Rev. Alerg México. 2014;61(2):81-9.
Larenas-Linnemann D, Ortega-Martell JA, Del Río-Navarro B, Rodríguez-Pérez N, Arias-Cruz A, Estrada A, et al. Guía Mexicana de práctica clínica de inmunoterapia 2011. RevAlergMex. 2011;58(1):3–51.
Yoo KH, Ahn HR, Park JK, Kim JW, Nam GH, Hong SK, Kim MJ, Ghoshal AG, Muttalif AR, Lin HC, Thanaviratananich S, Bagga S, Faruqi R, Sajjan S, Baidya S, Wang DY, Cho SH. Burden of Respiratory Disease in Korea: An Observational Study on Allergic Rhinitis, Asthma, COPD, and Rhinosinusitis. Allergy Asthma Immunol Res. 2016 Nov;8(6):527-534
Chen H, Li J, Cheng L, Gao Z, Lin X, Zhu R, Yang L, Tao A, Hong H, Tang W, Guo Y, Huang H, Sun J, Lai H, Lei C, Liu G, Xiang L, Chen Z, Ma H, Chan AWM, Hao C, Sun B. China Consensus Document on Allergy Diagnostics. Allergy Asthma Immunol Res. 2021 Mar;13(2):177-205. doi: 10.4168/aair.2021.13.2.177. PMID: 33474855; PMCID: PMC7840865.
