Keywords
Disorders
Diabetes Mellitus
MODY
Genetic Variation
Insulin-Secreting Cells
How to Cite
Abstract
MODY is a rare endocrinopathy originated from various genetic mutations that, independently of each other, express in the patient characteristics of a specific subtype of MODY, thirteen of which have been identified to date, however, only some of these subtypes have been delimited due to, among other factors, levels of overlapping of clinical characteristics and the need for genetic tests as the only definitive diagnostic resource.
The primary defect in pancreatic cell function, the absence of debut by ketoacidosis, the disease will affect three family generations, the diagnosis in childhood or adolescence, the low obesity index and evolution of slow progress without insulin treatment in the early stages of the disease, are the general characteristics of the Maturity Onset Diabetes of the Young. On the other hand, the diagnosis of MODY X is given to the identified patients whose genetic tests do not express mutations known to be associated to MODY but that present the clinical criteria.
References
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